منابع مشابه
Notch, a T-ALL order.
The data reported in this paper use a mouse model system where either the activated form of Notch1 (NotchIC) or c-Myc is under the control of the Tet operator and inducible by removal of doxycycline from the drinking water. Induction of either NotchIC or c-Myc is sufficient to drive the formation of T-cell leukemias that resemble human T-ALL. The authors have also used retroviral expression vec...
متن کاملFifty ways to Notch T-ALL.
The fireworks from the spectacular emergence of Notch as the protagonist in the etiology of T-ALL are not likely to end any time soon. Indeed, in this issue of Blood, Sulis and colleagues describe yet another sophisticated mechanism by which ligand-independent activation of NOTCH1 is achieved in T-ALL. NOTCH1activating mutations mark more than half of all T-ALL cases, underscoring the fundament...
متن کاملNotch Signaling in T-Cell Development and T-ALL
The Notch signaling pathway is an evolutionarily conserved cell signaling system present in most multicellular organisms, as it controls cell fate specification by regulating cell proliferation, differentiation, apoptosis, and survival. Regulation of the Notch signaling pathway can be achieved at multiple levels. Notch proteins are involved in lineage fate decisions in a variety of tissues in v...
متن کاملTrib2 Suppresses Tumor Initiation in Notch-Driven T-ALL
Trib2 is highly expressed in human T cell acute lymphoblastic leukemia (T-ALL) and is a direct transcriptional target of the oncogenic drivers Notch and TAL1. In human TAL1-driven T-ALL cell lines, Trib2 is proposed to function as an important survival factor, but there is limited information about the role of Trib2 in primary T-ALL. In this study, we investigated the role of Trib2 in the initi...
متن کاملNotch in T-ALL: new players in a complex disease.
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy of thymocytes affecting preferentially children and adolescents. The disease is heterogeneous and characterized by a large set of chromosomal and genetic alterations that deregulate the growth of maturing thymocytes. The identification of activating point mutations in NOTCH1 in more then 50% of all T-ALL cases...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2008
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2008.222